The Urinary Indicans Test is an accurate, screening tool that measures the putrefaction of protein in the gastrointestinal tract by dysbiotic bacteria.  A positive result indicates gastrointestinal toxicity as a result of dysbiosis.  


How Does Urinary Indicans Testing indicate GUT Abnormality?


The action of dysbiotic bacteria on tryptophan in the intestines produces Indicans.  Most Indicans is eliminated in the faeces.  The remainder is absorbed, detoxified and excreted in the urine.  In normal urine, the amount of Indicans excreted is small.


In the presence of leaky gut syndrome, a greater amount of Indicans enters the bloodstream and is filtered through the kidneys and appears in the urine.  


In constipation, waste material sits in the intestines for an extended period, and a larger amount of Indicans may appear in the urine. 


An alteration in normal flora in the intestines also contributes to a positive Indicans test. 


Causes of a Positive Indicans Test


*  Intestinal overgrowth of anaerobic bacteria (Dysbiosis)

*  Intestinal mucosal permeability

*  Protein maldigestion (or excessive intake)

*  Constipation

*  Bile duct obstruction or intrahepatic biliary obstruction

*  Accelerated protein decomposition anywhere in the body, such as septicaemia with abscess      formation



Conditions Associated with Increased Urinary Indicans


*  Achlorhydria

*  Coeliac Disease

*  Diminished peristalsis

*  Fungal infections

*  Gastric Ulcer

*  Hypermotility of the small intestine

*  Hypochlorhydria

*  Inflammatory Bowel Disease

*  Jejunal Diverticulosis

*  Lack of digestive enzymes

*  Liver problems

*  Malabsorptive syndromes

*  Pancreatic insufficiency

*  Parasitic infections

*  Scleroderma

*  Small Bowel Bacterial Overgrowth (SBBO)

*  Toxicity


Instructions for collection of urine sample.


*  The night before the test, please consume a high quality protein meal (Meat, Chicken or      fish)  

*  Do not consume alcohol in the 24 hours prior to the test.  Alcohol consumption can interfere      with the result.    

*  Collect the first morning urine sample in a clean container and retain for testing.  

*  Bring sample to appointment on that day.  Keep specimen cool, or refrigerate. 




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